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The amulet of drain resistance is a new amulet in SLASH'EM which provides drain resistance, as is provided in vanilla nethack only by wielding Stormbringer, Excalibur or the Staff of Aesculapius, the last of which no longer provides the intrinsic in SLASH'EM.
Due mainly to wands of draining, drain resistance becomes a necessity in SLASH'EM's late game. The amulet of drain resistance is a very good choice for fulfilling this, at least for those who would otherwise wear an amulet of life saving or an amulet of flying. Be aware that a fast monster may be able to drain 2 (or possibly even more) levels from you before you can replace your amulet, resulting in a loss of level that cannot be immediately undone.